ABSTRACT
Objective: The study was conducted to evaluate the ocular toxicity of ethambutol given in both intensive and continuation phases of treatment in children with drug-sensitive tuberculosis. Methods: A prospective study of 94 eyes from 47 patients receiving an ethambutol-containing regimen was conducted between 1 December, 2018 and 31 August, 2020. Visual acuity, visual field, visual evoked response (VER), contrast sensitivity, colour perception, and retinal nerve fiber layer (RNFL) thickness [using optical coherence tomography (OCT)] were tested for each patient before, during, and after the treatment. Results: On follow-up, visual acuity, color vision, contrast sensitivity, fundus, and visual fields were not affected in any of the patients. There was no statistically significant increase in the mean latency of the P(100) wave at any point in time. On OCT, no significant loss of mean RNFL thickness was detected. Conclusions: Ethambutol is safe to use up to a dose of 20 mg/kg/day throughout the entire course of anti-tubercular therapy in children with drug-sensitive tuberculosis
ABSTRACT
Background: The objective of this present study was to compare the efficacy of oral mifepristone and balloon catheter for cervical ripening and induction of labour in women with previous caesarean section.Methods: This prospective study was conducted on 130 pregnant women with previous 1 caesarean section and term singleton pregnancy admitted for induction of labour. Sixty-five patients were induced with oral mifepristone (Group 1) and in another 65 transcervical balloon catheter (Group 2) was inserted for induction of labour. Both groups were than compared with respect to change in bishop score, induction to active phase interval, induction to delivery interval, dose of oxytocin in milliunits, mode of delivery, maternal complication and fetal outcomes.Results: Change in bishop score after induction was more in mifepristone group than balloon catheter group (p=0.002). Favorable bishop score was more in Group 1 (83.07%) than Group 2 (66%), p=0.05. There was significant difference in mode of delivery between two groups, 61.53% in Group 1, and 32.3% in Group 2 delivered vaginally (p<0.001).Conclusions: Present study showed that mifepristone is an alternative to balloon catheter for induction of labour in women with previous one caesarean section with poor bishop score.
ABSTRACT
Abstract: Background& Objectives: Diabetic neuropathy is the most common and troublesome complication of diabetes mellitus, leading to great morbidity and resulting in burden for diabetes care. The progression of neuropathy can be reduced by early detection and intervention. Nerve conduction studies are the most sensitive indices of the severity of neuropathy. These tests can be used to localize lesions and describe the type and severity of the pathophysiologic process, including alterations that are not recognized clinically. This study was undertaken to compare nerve conduction study results in diabetes mellitus patients with good glycemic control and poor glycemic control and to compare it with non-diabetic subjects. This study aims to signify the role of nerve conduction study in diabetes mellitus. This can help in identifying the asymptomatic stage of diabetic neuropathy so that suitable preventive measures can be taken. Methodology: Total 90 subjects were included in the study group. 30 were non diabetic subjects and 60 were known cases of Type II diabetes mellitus patients attending diabetic OPD at GMCH, Aurangabad of age 30-50 years with duration of 5-10 years. Glycated haemoglobin levels were estimated and on this basis the cases were divided into two groups; diabetic patients with good glycemic control and diabetic patients with poor glycemic control. Nerve Conduction parameters were measured by computerized micromed RMSEMG system. Results: There was an increase in mean latency and decrease in amplitude and velocity values in both the diabetic groups. Intergroup comparison showed that, the increase in latency and decrease in amplitude and velocity was more in diabetics with poor glycemic control as compared to other study groups and this difference was statistically highly significant. Conclusion: The study concluded that there is statistically significant changes in nerve conduction parameters in Type II diabetes.